G908R NOD2 variant in a family with sarcoidosis.

Valérie BesnardAlain CalenderDiane BouvryYves PachecoCatherine Chapelon-AbricFlorence JenyHilario NunesCarole PlanèsDominique Valeyre

Published in: Respiratory research (2018)

Combination of polymorphisms in the NOD2, IL17RA, EPHA2 and KALRN genes could play a significant role in the development of sarcoidosis by maintaining a chronic pro-inflammatory status in macrophages.

Keyphrases

innate immune
rheumatoid arthritis
genome wide
disease activity
gene expression
bioinformatics analysis
dna methylation
genome wide analysis