Kynurenine pathway and autism spectrum phenotypes: an investigation among adults with autism spectrum disorder and their first-degree relatives.

Barbara CarpitaBenedetta NardiLionella PalegoIvan M CremoneGabriele MassimettiClaudia CarmassiLaura BettiGino GiannacciniLiliana Dell'Osso

Published in: CNS spectrums (2022)

Our findings confirm in adult samples the presence of altered TRP metabolism through KYN pathway. The intermediate alterations reported among relatives of ASD patients further stress the presence of a continuum between subthreshold and full-threshold ASD phenotypes also from a biochemical perspective.

Keyphrases

autism spectrum disorder
intellectual disability
end stage renal disease
ejection fraction
attention deficit hyperactivity disorder
newly diagnosed
peritoneal dialysis
prognostic factors
young adults
stress induced
patient reported