Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019.

Serge GrazioliFedora TavaglioneGiulia TorrianiNoemie WagnerMarie RohrArnaud G L'HuillierCharlotte LeclercqAnne PerrinAlice BordessouleMaurice BeghettiJana Pachlopnik SchmidStefano VavassoriMatthieu PerreauChristiane EberhardtArnaud DidierlaurentLaurent KaiserIsabella EckerlePascale Roux-LombardGeraldine Blanchard-Rohner

Published in: Journal of the Pediatric Infectious Diseases Society (2021)

Our findings suggest that MIS-C related to COVID-19 is caused by a postinfectious inflammatory syndrome associated with an elevation in all cytokines, and markers of recent T-cell activation (sIL-2R) occurring despite a strong and specific humoral response to SARS-CoV-2. Further functional and genetic analyses are essential to better understand the mechanisms of host-pathogen interactions.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
oxidative stress
immune response
case report
genome wide
gene expression
young adults