Login / Signup

Advances in intravesical therapy for bladder pain syndrome (BPS)/interstitial cystitis (IC).

En MengYu-Chao HsuYao-Chi Chuang
Published in: Lower urinary tract symptoms (2018)
Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic symptom complex that may cause bothersome storage symptoms and pain or discomfort of the bladder, adversely affecting a patient's quality of life. The etiology of IC/BPS remains unclear, and its cause may be multifactorial. Diagnosis of IC/BPS is based on clinical features, and the possibility of other conditions must be ruled out first. Although no definitive treatment is currently available for IC/BPS, various intravesical therapies are used for IC/BPS, including heparin, hyaluronic acid, chondroitin sulfate, pentosan polysulfate, dimethylsulfoxide, liposomes, and botulinum onabotulinumtoxinA (BoNT-A). This review summarizes the intravesical therapy for IC/BPS and discusses recent advances in the instillation of liposomal-mediated BoNT-A and other newly developed intravesical therapies.
Keyphrases
  • urinary tract
  • hyaluronic acid
  • spinal cord injury
  • muscle invasive bladder cancer
  • chronic pain
  • neuropathic pain
  • pain management
  • physical activity
  • drug release
  • locally advanced