Computer Vision Analysis of Rheumatoid Arthritis Synovium Reveals Lymphocytic Inflammation is Associated with Immunoglobulin Skewing in Blood.

Damon FrezzaEdward DiCarloCaryn HaleDaniel RamirezBella MehtaDavid SlaterSaimun HabibMayu O Frank NpEdoardo SpolaoreMelanie H SmithLaura DonlinSusan M GoodmanJames R ThompsonDana E Orange

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

High resolution automated identification and quantification of synovial immune cell aggregates uncovered skewing in the synovium from naive IGHD and IGHM to memory IGHG3 and IGHG1 and revealed that this process is reflected in the blood of patients with high inflammatory synovium. This article is protected by copyright. All rights reserved.

Keyphrases

rheumatoid arthritis
high resolution
oxidative stress
deep learning
machine learning
high throughput
disease activity
hiv infected
working memory
single cell
mass spectrometry
interstitial lung disease
systemic lupus erythematosus