Neurotoxicity of different amyloid beta subspecies in mice and their interaction with isoflurane anaesthesia.

Laura Borgstedt Manfred Blobner Maximilian MusiolSebastian BratkeFinn SyrycaGerhard RammesBettina Jungwirth Sebastian Schmid

Published in: PloS one (2020)

Testing cognitive performance after intracerebroventricular injection of different amyloid beta subspecies revealed that Aβ pyro might be less harmful, which was reversed by isoflurane anaesthesia. There is minor evidence for Aβ42-mediated neurotoxicity. Preliminary molecular analysis of biomarkers did not clarify pathophysiological mechanisms.

Keyphrases

single cell
metabolic syndrome
single molecule
adipose tissue
skeletal muscle
wild type
insulin resistance