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hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer.

Mark Nathaniel AdamsLaura V CroftAaron UrquhartMohamed Ashick Mohamed SaleemAnja RockstrohPascal H G DuijfPatrick B ThomasGenevieve P FergusonIdris Mohd NajibEsha T ShahEmma BoldersonShivashankar NagarajElizabeth D WilliamsColleen C NelsonKenneth J O'ByrneDerek J Richard
Published in: The Prostate (2023)
Our findings point to a key role for hSSB1 in mediating the cellular response to androgen and DNA damage via modulation of transcription. Exploiting hSSB1 in PCa might yield benefits as a strategy to ensure a durable response to ADT and/or radiotherapy and improved patient outcomes.
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