hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer.

Mark Nathaniel AdamsLaura V CroftAaron UrquhartMohamed Ashick Mohamed SaleemAnja RockstrohPascal H G DuijfPatrick B ThomasGenevieve P FergusonIdris Mohd NajibEsha T ShahEmma BoldersonShivashankar NagarajElizabeth D WilliamsColleen C NelsonKenneth J O'ByrneDerek J Richard

Published in: The Prostate (2023)

Our findings point to a key role for hSSB1 in mediating the cellular response to androgen and DNA damage via modulation of transcription. Exploiting hSSB1 in PCa might yield benefits as a strategy to ensure a durable response to ADT and/or radiotherapy and improved patient outcomes.

Keyphrases

dna damage
prostate cancer
oxidative stress
dna repair
transcription factor
diabetic rats
high glucose
early stage
radical prostatectomy
gene expression
radiation therapy
locally advanced
radiation induced
drug induced
endothelial cells
heat shock
rectal cancer