The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status.

Michael OukChe-Yuan WuJennifer S RabinAaron JacksonJodi D EdwardsJoel RamirezMario MasellisRichard H SwartzNathan HerrmannKrista L LanctôtSandra E BlackWalter Swardfager

Published in: Alzheimer's research & therapy (2021)

Among APOE ε4 non-carriers with AD, ARB use was associated with greater preservation of memory and attention/psychomotor processing speed, particularly compared to ACE-Is that do not cross the blood-brain-barrier.

Keyphrases

cognitive decline
angiotensin converting enzyme
blood brain barrier
angiotensin ii
working memory
mild cognitive impairment
cerebral ischemia
metabolic syndrome
binding protein
skeletal muscle