Generation of a Novel Mesothelin-Targeted Oncolytic Herpes Virus and Implemented Strategies for Manufacturing.

Guendalina FroechlichChiara GentileLuigia InfanteCarmen CaiazzaPasqualina PaganoSarah ScatignaGabriella CotugnoAnna Morena D'AliseArmin LahmElisa ScarselliAlfredo NicosiaMassimo MallardoEmanuele SassoNicola Zambrano

Published in: International journal of molecular sciences (2021)

Our proof-of-concept study proposes MSLN-retargeted herpesviruses as potential cancer immunotherapeutics for assessments in preclinical models of MSLN-positive tumors, complementing the available panel of oncolytic viruses to HER2-negative breast tumors.

Keyphrases

papillary thyroid
squamous cell
cancer therapy
stem cells
human health
childhood cancer
drug delivery
risk assessment
young adults
mesenchymal stem cells
bone marrow
genetic diversity