Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response.
Ruiping WangShumei SongKazuto HaradaFatemeh Ghazanfari AmlashiBrian BadgwellMelissa Pool PizziYan XuWei ZhaoXiaochuan DongJiangkang JinYing WangAiling ScottLang MaLongfei HuoDiego VicenteMariela Blum MurphyNamita ShanbhagGhia TatlonghariIrene ThomasJane RogersMakoto KobayashiJody VykoukalJeannelyn Santiano EstrellaSinchita Roy-ChowdhuriGuangchun HanShaojun ZhangXizeng MaoXingzhi SongJianhua ZhangJian GuRandy L JohnsonGeorge Adrian CalinGuang PengJu-Seog LeeSamir M HanashAndrew FutrealZhenning WangLinghua WangJaffer A AjaniPublished in: Gut (2019)
We have uncovered the unique mutational landscape, copy number alteration and gene expression profile of PC cells and defined PC molecular subtypes, which correlated with PC therapy resistance/response. Novel targets and immune checkpoint proteins have been identified with a potential to be translated into clinics.