Different ratios of supercoiled to relaxed mtDNA influence the inflammatory response of cardiomyocytes and contribute to HF through the involvement of ZBP1. ZBP1, together with its downstream inflammatory mechanisms, mediates the inflammatory response induced by a low ratio of supercoiled mtDNA.
Keyphrases
- inflammatory response
- mitochondrial dna
- copy number
- lipopolysaccharide induced
- heart failure
- lps induced
- toll like receptor
- left ventricular
- oxidative stress
- acute heart failure
- aortic valve
- neuropathic pain
- genome wide
- dna methylation
- adipose tissue
- high fat diet induced
- pulmonary hypertension
- immune response
- atrial fibrillation
- gene expression
- coronary artery
- pulmonary arterial hypertension
- spinal cord