White blood cells and chronic rhinosinusitis: a Mendelian randomization study.

Thanai PongdeeSuzette J BielinskiPaul A DeckerHirohito KitaNicholas B Larson

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2022)

In a two-sample MR analysis, a potential causal link between blood eosinophil counts and CRS has been demonstrated. In addition, causal relationships between blood counts among other white blood cell types and CRS were not found. Further studies involving genetic variation in CRS are needed to corroborate genetic causal effects for CRS.

Keyphrases

induced apoptosis
chronic rhinosinusitis
magnetic resonance imaging
peripheral blood
computed tomography
genome wide
cell therapy
dna methylation
cell proliferation
copy number
cell death
mesenchymal stem cells
endoplasmic reticulum stress
case control