Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma.

Zachary L WatsonTomomi M YamamotoAlexandra McMellenHyunmin KimConnor J HughesLindsay J WheelerMiriam D PostKian BehbakhtBenjamin G Bitler

Published in: Clinical epigenetics (2019)

This study demonstrates that disrupting EHMT1/2 sensitizes HGSOC cells to PARPi, and suggests a potential mechanism through DNA damage and cell cycle dysregulation. RNA-Seq identifies several unexplored pathways that may alter PARPi resistance. Further study of EHMT1/2 and regulated genes will facilitate development of novel therapeutic strategies to successfully treat HGSOC.

Keyphrases

high grade
cell cycle
dna damage
rna seq
induced apoptosis
single cell
cell proliferation
dna repair
oxidative stress
dna methylation
low grade
gene expression
cell cycle arrest
endoplasmic reticulum stress
pi k akt