DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.
Ashley Pitzer MutchlerFernando ElijovichCheryl L LafferLale A ErtugluMelis SahinozMohammad SaleemJaya KrishnanThanvi DolaLuul A AdenQuanhu ShengMichael A RaddatzCelestine N WanjallaSuman PakalaSean S DaviesDavid M PatrickValentina KonT Alp IkizlerThomas R KleymanAnnet KiraboPublished in: Circulation research (2022)
These findings reveal a mechanistic link between ENaC, inflammation, and salt-sensitive hypertension involving NLRP3 inflammasome activation in APCs. APC activation via the NLRP3 inflammasome can serve as a potential diagnostic biomarker for salt sensitivity of blood pressure.