Fenton-like Reaction Inspired "·OH Catalyzed" Osteogenic Process for the Treatment of Osteoporosis.
Jingcheng WangJing YeGuoyu YangJialiang XieXinxin MiaoJianjian DengTianlong WuXigao ChengXiaolei WangPublished in: Advanced healthcare materials (2024)
Inspired by the Fenton-like reaction, this work combines copper peroxide (CP) nanoparticles with black phosphorus (BP) nanosheets to form a hydroxyl radical (·OH)-centered "catalytic" osteogenic system. CP-produced ·OH interacts with BP to rapidly produce a large amount of phosphate ions, thus accelerating self-mineralization and promoting bone formation. In turn, BP not only exerts anti-inflammatory effects, thereby providing a favorable microenvironment for bone formation, but also offsets the potential toxicity of CP induced by reactive oxygen species (ROS). Together with copper ions (Cu 2+ ), phosphate ions are also released as a byproduct of this process, which can contribute to the comprehensive promotion of osteogenesis.
Keyphrases
- reactive oxygen species
- quantum dots
- aqueous solution
- mesenchymal stem cells
- bone marrow
- hydrogen peroxide
- sensitive detection
- wastewater treatment
- oxide nanoparticles
- stem cells
- postmenopausal women
- oxidative stress
- dna damage
- cell death
- reduced graphene oxide
- gold nanoparticles
- highly efficient
- electron transfer
- sewage sludge