Development and Biodistribution of a Nerve Growth Factor Radioactive Conjugate for PET Imaging.
R A CarrascoA K SalihM Dominguez GarciaE S KhozeimehG P AdamsC P PhenixEric W PricePublished in: Molecular imaging and biology (2023)
We conclude that conjugation of DFO to NGF through a thiourea linkage allows effective radiolabeling with zirconium-89 while maintaining NGF bioactivity. Following intravenous administration, the radiolabeled NGF targets non-neuronal tissues (e.g., kidney, liver), and although absolute brain uptake was very low, the brain uptake that was observed was restricted to the cortex.