Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma.

Simin LiYang WangRui SunDebora FranceschiHongying PanChenxuan WeiAnthony Chukwunonso Ogbuehi Bernd Lethaus Vuk Savković Sebastian GausRüdiger ZimmererDirk ZiebolzGerhard Schmalz Xiao Jiang

Published in: Journal of immunology research (2022)

This study revealed dynamic changes in cell percentage and heterogeneity of cell subtypes of HNSCC. AREG, TGFBI, CD27, CXCR3, MS4A1, and CD19 were associated with worse overall survival in HPV-related HNSCC. Especially B-cell related pathways were revealed as particularly relevant in HPV-related HNSCC. These findings are a basis for the development of biomarkers and therapeutic targets in respective patients.

Keyphrases

single cell
rna seq
high grade
high throughput
end stage renal disease
ejection fraction
chronic kidney disease
cell therapy
mass spectrometry
multiple sclerosis
peritoneal dialysis
gene expression
stem cells
genome wide
dna methylation
bone marrow
nk cells
mesenchymal stem cells
induced pluripotent stem cells