Plasma polyamines during pregnancy and their relationships with maternal allergies and the immune response of the neonates.

Antonio Gázquez Azahara María García-Serna Trinidad Hernández-Caselles Elena Martín-OrozcoEsther Cantero-CanoMaría T Prieto-SánchezMaría D Molina-RuanoRafaela Castillo-LacalleJesús VioqueEva MoralesGarcía-Marcos Luis Elvira Larquénull null

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2024)

Spermidine and spermine are the predominant polyamines in plasma of pregnant women at mid-pregnancy and also in umbilical cord. Maternal allergic diseases like allergic conjunctivitis are related to lower levels of polyamines in cord vein, which could influence the immune response of the newborn. Cord polyamine content is related to a decreased Th2 response and inflammatory cytokines production, which might be important to reduce an allergenic phenotype in the neonate.

Keyphrases

immune response
pregnancy outcomes
umbilical cord
pregnant women
mesenchymal stem cells
birth weight
dendritic cells
allergic rhinitis
toll like receptor
preterm birth
low birth weight
atopic dermatitis
body mass index
gestational age
weight gain
physical activity
drug induced