Cerebrospinal fluid complement system biomarkers in demyelinating disease.
Wioleta Milena ZelekDina FathallaAngharad MorganSamuel TouchardSamantha LovelessEmma Clare TallantyreNeil P RobertsonB Paul MorganPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)
Compared to control CSF, (1) levels of C4, C1INH and Properdin were elevated in MS; (2) TCC, iC3b, FI and FHR125 were increased in CIS; and (3) all complement biomarkers except TCC, FHR125, Properdin and C5 were higher in NMOSD CSF. A statistical model comprising six analytes (C3, C9, FB, C1q, FI, Properdin) plus age/gender optimally differentiated MS from NMOSD.