Cascade photoredox/gold catalysis: access to multisubstituted indoles via aminoarylation of alkynes.
Chuanhua QuSong Lin ZhangHongbin DuChengjian ZhuPublished in: Chemical communications (Cambridge, England) (2018)
A new method for the synthesis of 3-arylindoles has been developed by visible light mediated dual gold/photoredox catalysis. This transformation has many features such as cascade catalysis, high efficiency, redox-neutral reaction conditions and good functional group tolerance. The reaction proceeds through the photoredox-promoted formation of an electrophilic arylgold(iii) intermediate that undergoes coupling with the arylamine nucleophile.