SARS-CoV-2 antibody prevalence by industry, workplace characteristics, and workplace infection prevention and control measures, North Carolina, 2021 to 2022.

High numbers of COVID-19 outbreaks, cases, and deaths have been reported among livestock industry workers, including Black and Hispanic workers, in the United States. Little is known about SARS-CoV-2 infection as measured by antibody prevalence in this setting. Antibody-based estimates of SARS-CoV-2 infection can capture cases missed by SARS-CoV-2 molecular testing, which is important given limitations in worker access to molecular diagnostic testing. We observed high SARS-CoV-2 infection-induced IgG prevalence in animal slaughtering and processing industry workers (71%) between February 2021 and August 2022, which is 1.5 to 4.3 times higher compared to the North Carolina general population, as well as higher than molecularly-confirmed cases and the only serology study we identified of animal slaughtering and processing workers. We also found higher odds of SARS-CoV-2 infection among participants at worksites with larger compared to smaller numbers of employees.