Extracorporeal membrane oxygenation outcomes in children with Williams syndrome: a review of the ELSO registry.
Amarilis A MartinPeter T RycusAhmad FarooqiJohn DentelKatherine CashenPublished in: Perfusion (2021)
Included were 50 WS children and 1222 non-WS children with similar cardiac diagnoses. ECMO use increased over time in both groups (p = 0.93), with most cases occurring in the current era. WS children were younger (p = 0.004), weighed less (p = 0.048), had a pulmonary indication for ECMO (50% vs 10%, p < 0.001), and were placed more on high frequency ventilation (p < 0.001) than non-WS patients. Despite reporting a respiratory indication, most (84%) WS patients were placed on VA-ECMO. There were no significant differences between the two groups in terms of pre-ECMO cardiac arrest, ECMO duration, or reason for ECMO discontinuation. Both groups had a mortality rate of 48% (p = 1.00). No risk factors for WS mortality were identified.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- respiratory failure
- high frequency
- young adults
- end stage renal disease
- cardiac arrest
- mechanical ventilation
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- emergency department
- type diabetes
- cardiovascular disease
- pulmonary hypertension
- coronary artery disease
- intensive care unit
- patient reported