Hypocrellin A against intrahepatic Cholangiocarcinoma via multi-target inhibition of the PI3K-AKT-mTOR, MAPK, and STAT3 signaling pathways.

Bo ChenQiwen ChenMengmeng LuEnguang ZouGanglian LinJiangqiao YaoLushuang WangYuqian GanBicheng ChenGang ChenLijun Wu

Published in: Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)

HA, a novel natural small molecule, demonstrated promising therapeutic efficacy against ICC through its multi-target inhibitory effects on the PI3K-AKT-mTOR, MAPK, and STAT3 signaling pathways. Moreover, it exhibited notable therapeutic benefits in a primary ICC model (KRAS/P19/SB), positioning it as a novel therapeutic agent for ICC.

Keyphrases

signaling pathway
pi k akt
small molecule
cell proliferation
induced apoptosis
epithelial mesenchymal transition
oxidative stress
protein protein