Pharmacokinetic and pharmacodynamic properties of orally administered torasemide in healthy cats.
Marine Roche-CatholyDominique PaepeMathias DevreeseBart J G BroeckxFrederique WoehrléMarc SchneiderAndrea Garcia de Salazar AlcalaArnaut HellemansPascale SmetsPublished in: Journal of veterinary internal medicine (2022)
A single torasemide dose leads to a significant increase in diuresis and renin-angiotensin-aldosterone system (RAAS) activation in healthy cats, with high absolute bioavailability, and without clinically relevant adverse effects. Pharmacokinetic parameters indicate that once daily dosing of 0.27 mg/kg may be appropriate in a clinical setting.