A Multi-Ligand Imaging Study Exploring GABAergic Receptor Expression and Inflammation in Multiple Sclerosis.

Yeona KangSandra Milena Hurtado RúaUlrike W KaunznerJai PerumalNancy NealonWenchao QuParesh J KothariTimothy VartanianAmy KuceyeskiSusan A Gauthier

Published in: Molecular imaging and biology (2021)

A higher GABAA receptor density in MS subjects compared with HC was observed and correlated with innate immune activity. Our observations demonstrate that immune-driven GABAergic abnormalities may be present in MS.

Keyphrases

multiple sclerosis
innate immune
mass spectrometry
ms ms
oxidative stress
high resolution
white matter
fluorescence imaging