Single-cell profiling reveals age-associated immunity in atherosclerosis.
Virginia SmitJill de MolFrank H SchaftenaarMarie A C DepuydtRimke J PostelDiede SmeetsFenne W M VerheijenLaurens BogersJanine van DuijnRobin A F VerwilligenHendrika W GrievinkMireia N A Bernabé KleijnEva van IngenMaaike J M de JongLauren GoncalvesJudith A H M PeetersHarm J SmeetsAnouk WezelJulia K PolanskyMenno P J de WintherChristoph J BinderDimitrios TsiantoulasIlze BotJohan KuiperAmanda C FoksPublished in: Cardiovascular research (2023)
Collectively, we are the first to provide comprehensive profiling of aged immunity in atherosclerotic mice and reveal the emergence of age-associated T- and B-cells in the atherosclerotic aorta. Further research into age-associated immunity may contribute to novel diagnostic and therapeutic tools to combat cardiovascular disease.