Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance.

Xiao-Feng LiCheng ChenDai-Min XiangLe QuWen SunXin-Yuan LuTeng-Fei ZhouShu-Zhen ChenBei-Fang NingZhuo ChengMing-Yang XiaWei-Feng ShenWen YangWen WenTerence Kin-Wah LeeWen-Ming CongHong-Yang WangJin Ding

Published in: Hepatology (Baltimore, Md.) (2017)

Our results not only clarify the cellular and molecular mechanisms underlying the inflammation-mediated LCSC generation but also provide a molecular classification for the individualized treatment of liver cancer. (Hepatology 2017;66:1934-1951).

Keyphrases

stem cells
oxidative stress
machine learning
single molecule
combination therapy
mesenchymal stem cells