Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth.

Anne Marijne HeerenJossie RotmanSanne SamuelsHenry J M A A ZijlmansGuus FonsKoen K van de VijverMaaike C G BleekerGemma G KenterEkaterina J JordanovaTanja D de Gruijl

Published in: Journal for immunotherapy of cancer (2022)

Metastatic spread in vulvar TDLN is marked by an inflamed microenvironment with activated effector T cells, which are likely kept in check by an interplay of suppressive feedback mechanisms. Our data support (neoadjuvant) TDLN-targeted therapeutic interventions based on CTLA-4 and PD-1 blockade, to reinvigorate memory T cells and curb early metastatic spread and growth.

Keyphrases

lymph node
squamous cell carcinoma
small cell lung cancer
sentinel lymph node
stem cells
physical activity
rectal cancer
regulatory t cells
dendritic cells
working memory
cancer therapy
big data
immune response
machine learning
young adults