Whole-exome sequencing of transforming oral lichen planus reveals mutations in DNA damage repair and apoptosis pathway genes.

Fangyi XieCasey A GleueMaria DeschaineSurendra DasariJulie S LauJulio C Sartori-ValinottiAlexander MevesJulia S Lehman

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)

These findings suggest alterations in DNA damage response and apoptosis pathways underlie lichen planus-related oral squamous cell carcinoma transformation and are supported by mutational signatures indicative of DNA damage. This study characterized patterns of mutational events present in oral lichen planus associated with squamous cell carcinoma and in squamous cell carcinoma associated with oral lichen planus but not in non-transforming oral lichen planus.

Keyphrases

dna damage
squamous cell carcinoma
oxidative stress
dna damage response
dna repair
endoplasmic reticulum stress
cell death
genome wide
cell cycle arrest
lymph node metastasis
locally advanced
radiation therapy
cell proliferation
transcription factor
rectal cancer
pi k akt