Loss of Cavin-2 destabilizes PTEN and enhances Akt signaling pathway in cardiomyocytes.

Naoki MaruyamaTakehiro OgataTakeru KasaharaTetsuro HamaokaYusuke HiguchiYumika TsujiShinya TomitaAkira SakamotoNaohiko NakanishiSatoaki Matoba

Published in: Cardiovascular research (2024)

Cavin-2 plays a negative regulator in the PI3K-Akt signaling in CMs through interaction with PTEN. Loss of Cavin-2 enhances Akt activity by promoting PTEN destabilization, which promotes physiological CM hypertrophy and may enhance Akt-mediated cardioprotective effects against pathological CM hypertrophy.

Keyphrases

signaling pathway
pi k akt
cell proliferation
induced apoptosis
epithelial mesenchymal transition
transcription factor
oxidative stress