Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury.

Asmita ChoudhuryDaniel BullockArlene LimJosepmaria ArgemiPontus OrningEgil LienRamon BatallerPranoti Mandrekar

Published in: Alcoholism, clinical and experimental research (2020)

Our studies indicate that inhibition of HSP90 and activation of HSF1/HSPA1A reduce IL-1β and IL-18 via decrease in NLRP3/CASP-1 and GSDMD activity in ALD.

Keyphrases

heat shock
nlrp inflammasome
liver injury
heat shock protein
drug induced
heat stress
oxidative stress
case control