CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival.
Camille DanneChloé MichaudelJurate SkerniskyteJulien PlanchaisAurélie MagniezAllison AgusMarie-Laure MichelBruno LamasGregory Da CostaMadeleine SpatzCyriane OeuvrayChloé GalbertMaxime PoirierYazhou WangAlexia LapièreNathalie RolhionTatiana LedentCédric PionneauSolenne ChardonnetFloriant BellvertEdern CahoreauAmandine RocherRafael Rose ArguelloCarole PeyssonnauxSabine LouisMathias L RichardPhilippe LangellaJamel El-BennaBenoit MarteynHarry SokolPublished in: Gut (2022)
These results provide new insight into the role of CARD9 in neutrophil mitochondrial function and its involvement in intestinal inflammation, paving the way for new therapeutic strategies targeting neutrophils.