Plasma Metabolomics Analysis of Aspirin Treatment and Risk of Colorectal Adenomas.

Elizabeth L Barry Veronika Fedirko Yutong Jin Ken H Liu Leila A Mott Janet L Peacock Michael N Passarelli John A Baron Dean P Jones

Published in: Cancer prevention research (Philadelphia, Pa.) (2022)

This research used metabolomics, an innovative discovery-based approach, to identify molecular changes in human blood that may help to explain how aspirin use reduces the risk of colorectal neoplasia in some individuals. Ultimately, this work could have important implications for optimizing aspirin use in the prevention of colorectal cancer.

Keyphrases

low dose
cardiovascular events
antiplatelet therapy
mass spectrometry
endothelial cells
small molecule
anti inflammatory drugs
high grade
acute coronary syndrome
percutaneous coronary intervention
coronary artery disease
cardiovascular disease
induced pluripotent stem cells
high throughput
single cell