D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner.

Xueman Zhou Yingcheng ZhengWentian SunZhenzhen Zhang Jia-Qi LiuWenke YangWenxiu YuanYating Yi Jun Wang Jin Liu

Published in: Cell proliferation (2021)

D-mannose alleviates osteoarthritis progression by suppressing HIF-2α-mediated chondrocyte sensitivity to ferroptosis, indicating D-mannose to be a potential therapeutic strategy for ferroptosis-related diseases.

Keyphrases

cell death
rheumatoid arthritis
knee osteoarthritis
endothelial cells
signaling pathway
mouse model
extracellular matrix