Inhibitory effects of aloin on TGFBIp-mediated septic responses.
In-Chul LeeJong Sup BaePublished in: Journal of Asian natural products research (2020)
Aloin is the major anthraquinone glycoside obtained from the Aloe species. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein and released by primary human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. We hypothesized that aloin could reduce TGFBIp-mediated severe inflammatory responses in HUVECs and mice. Aloin effectively inhibited lipopolysaccharide (LPS)-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. Aloin suppressed TGFBIp-induced sepsis lethality and pulmonary injury. Therefore, aloin is a potential therapeutic agent for various severe vascular inflammatory diseases, with inhibition of the TGFBIp signaling pathway as the mechanism of action. [Formula: see text].
Keyphrases
- lps induced
- transforming growth factor
- acute kidney injury
- extracellular matrix
- high glucose
- endothelial cells
- inflammatory response
- epithelial mesenchymal transition
- signaling pathway
- drug induced
- diabetic rats
- early onset
- oxidative stress
- pulmonary hypertension
- pi k akt
- protein protein
- cell proliferation
- skeletal muscle
- immune response
- insulin resistance
- human milk
- vascular endothelial growth factor
- low birth weight
- stress induced