Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ.

Juan AguileraXiaorui HanShu CaoJohn BalmesFred LurmannTim TynerLiza LutzkerElizabeth NothS Katharine HammondVanitha SampathTrevor BurtP J UtzPurvesh KhatriNima AghaeepourHolden MaeckerMary PrunickiKari Christine Nadeau

Published in: Clinical epigenetics (2022)

Exposure to several AAPs was negatively associated with T-helper subsets involved in pro-inflammatory and anti-inflammatory responses during pregnancy. Methylation of IL4, IL10, and IFNγ genes with pollution exposure confirms previous research. These results offer insights into the detrimental effects of air pollution during pregnancy, the demand for more epigenetic studies, and mitigation strategies to decrease pollution exposure during pregnancy.

Keyphrases

air pollution
particulate matter
heavy metals
dna methylation
dendritic cells
genome wide
risk assessment
gene expression
climate change
health risk assessment
regulatory t cells
chronic obstructive pulmonary disease
cystic fibrosis
bioinformatics analysis