Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside.
Márta SárközyZoltán VargaRenáta GáspárGergő SzűcsMónika Gabriella KovácsZsuzsanna Z A KovácsLászló DuxZsuzsanna KahánTamás CsontPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2021)
Cancer management has undergone significant improvements, which led to increased long-term survival rates among cancer patients. Radiotherapy (RT) has an important role in the treatment of thoracic tumors, including breast, lung, and esophageal cancer, or Hodgkin's lymphoma. RT aims to kill tumor cells; however, it may have deleterious side effects on the surrounding normal tissues. The syndrome of unwanted cardiovascular adverse effects of thoracic RT is termed radiation-induced heart disease (RIHD), and the risk of developing RIHD is a critical concern in current oncology practice. Premature ischemic heart disease, cardiomyopathy, heart failure, valve abnormalities, and electrical conduct defects are common forms of RIHD. The underlying mechanisms of RIHD are still not entirely clear, and specific therapeutic interventions are missing. In this review, we focus on the molecular pathomechanisms of acute and chronic RIHD and propose preventive measures and possible pharmacological strategies to minimize the burden of RIHD.
Keyphrases
- radiation induced
- heart failure
- radiation therapy
- spinal cord
- pulmonary hypertension
- papillary thyroid
- liver failure
- gene expression
- primary care
- physical activity
- drug induced
- palliative care
- diffuse large b cell lymphoma
- mitral valve
- aortic valve
- respiratory failure
- case report
- left ventricular
- early stage
- coronary artery disease
- aortic dissection
- acute heart failure
- cardiac resynchronization therapy
- hepatitis b virus
- transcatheter aortic valve replacement
- smoking cessation
- locally advanced
- single molecule