Design of a specific peptide against phenolic glycolipid-1 from Mycobacterium leprae and its implications in leprosy bacilli entry.

Nelson Enrique ArenasGilles PieffetCristian Rocha-RoaMartha Inírida Guerrero

Published in: Memorias do Instituto Oswaldo Cruz (2022)

Our LAMA2-based peptide targeting PGL-1 might have the potential to specifically block this key molecule, suggesting that the preferential region of the peptide is involved in the initial contact during the attachment of leprosy bacilli to Schwann cells.

Keyphrases

gram negative
induced apoptosis
mycobacterium tuberculosis
cell cycle arrest
cell death
muscular dystrophy