Concave P-Stereogenic Phosphorodiamidite Ligands for Enantioselective Rh(I) Catalysis.

Nidal Saleh Céline Besnard Jérôme Lacour

Published in: Organic letters (2024)

The development of a new class of concave P-stereogenic phosphorodiamidite ligands, derived from Tröger's bases (TBs), is explored. These ligands, characterized by their remarkable stability and unique structural geometry around the P atom, are used in asymmetric Rh(I)-catalyzed additions of boronic acids to NH-isatins resulting in excellent reactivities and reasonable enantioselectivity (er up to 92:8).

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