Computation-Guided Design of a Stimulus-Responsive Multienzyme Supramolecular Assembly.

Lu YangElliott M DolanSophia K TanTianyun LinEduardo D SontagSagar D Khare

Published in: Chembiochem : a European journal of chemical biology (2017)

The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed a phosphorylation- and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3-trichloropropane.

Keyphrases

cancer therapy
wastewater treatment
water soluble
human health
risk assessment
protein kinase