Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly.
Juan P Aguilar TiconaNivison NerySimon Doss-GollinClaudia GambrahMillani LessaValmir N Rastely-JuniorAdriana MatosBruno de Paula FreitasAna BorjaElsio A WunderVerena BallalaiCarina VieiraJaqueline S CruzDaiana de OliveiraDanielle Bastos AraujoDanielle B OliveiraDenicar Lina Nascimento Fabris MaedaÉrica A MendesCamila Pereira SoaresEdison L DurigonLuis Carlos de Souza FerreiraRubens BelfortAntonio R P AlmeidaJamary Oliveira-FilhoMitermayer G ReisAlbert I KoFederico CostaPublished in: PloS one (2021)
Children with CZS-associated microcephaly demonstrate severe neurodevelopmental delays and slower growth rates than their peers over time. Still, they have remarkably heterogeneous neurodevelopmental profiles according to neurological exam scores which correlate with their long-term outcomes. We found that HINE scores effectively captured the heterogeneity of neurological capabilities among these children and could be predictive of cognitive and motor development progress.