Function of gold nanoparticles in oral cancer beyond drug delivery: Implications in cell apoptosis.

Marwa M EssawySahar M El-SheikhHanaa S RaslanHeba S RamadanBin KangIman Mamdouh Talaat Marwa M Afifi

Published in: Oral diseases (2020)

Our findings suggest that AuNPs enhance the cytotoxic effect against cancer cells in addition to acting as drug carriers. DOX pH-resistant AuNPs enhanced accumulation of AuNPs in cancer cells' nuclei inducing a significant cellular apoptosis which was confirmed using in vitro and in vivo experiments without deleterious effects on blood cell count.

Keyphrases

gold nanoparticles
drug delivery
single cell
oxidative stress
endoplasmic reticulum stress
cell therapy
cell proliferation
cell death
cell cycle arrest
cancer therapy
peripheral blood
stem cells
drug induced
drug release
electronic health record