Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis.

Zivile UseckaiteMark P WardAnne TrappeRebecca ReillyJenny LennonHolly DavageDavid MatallanasHilary CassidyEugene T DillonKiva BrennanSarah L DoyleSuzanne CarterSeamas C DonnellyBarry LinnaneEdward F McKonePaul McNallyJudith A Coppinger

Published in: Thorax (2020)

This study demonstrates that EVs are produced in CF airway cells, have differential protein expression at different ages and drive neutrophil recruitment in CF.

Keyphrases

cystic fibrosis
pseudomonas aeruginosa
induced apoptosis
lung function
cell cycle arrest
oxidative stress
signaling pathway
chronic obstructive pulmonary disease
cell death