Increased circulating Cathepsin-K levels reflect PTH control in chronic hemodialysis patients.

Davide BolignanoMarta GrecoValentina ArcidiaconoOmar TripolinoCaterina VitaMichele ProvenzanoCinzia DonatoSalvatore ChiarellaGiorgio FuianoGiovambattista De SarroEmilio RussoMichele AndreucciDaniela Patrizia FotiGiuseppe Coppolino

Published in: Journal of nephrology (2020)

In chronic HD patients, Cathepsin-K associates with PTH levels, raising the intriguing hypothesis that this protein represents a causal link between mineral and inflammatory complications and could be tested as a candidate biomarker of MBD severity and PTH balance.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
binding protein