IL-33 Signaling Inhibition Leads to a Preeclampsia-Like Phenotype in Pregnant Rats.

Xi WangCorbin A ShieldsDeanna ThompsonJie McKayRachel WilsonMarcus K RobbinsHannah GlennMolly FontenotJan M WilliamsDenise C Cornelius

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)

Data presented in this study demonstrate a role for IL-33 signaling in controlling vascular function and maternal blood pressure during pregnancy possibly by mediating innate and adaptive immune inflammatory responses, identifying the IL-33 signaling pathway as a potential therapeutic target for managing preeclampsia.

Keyphrases

blood pressure
signaling pathway
early onset
pregnancy outcomes
immune response
pregnant women
electronic health record
risk assessment
metabolic syndrome
machine learning
body mass index
oxidative stress
birth weight
data analysis
weight gain