Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease.
Cong-Rong ShenXiao-Yu JiaWentian LuoFlorina OlaruZhao CuiMing-Hui ZhaoDorin-Bogdan BorzaPublished in: Journal of the American Society of Nephrology : JASN (2021)
Besides α345(IV) collagen, laminin-521 is another major autoantigen targeted in anti-GBM disease. Autoantibodies to laminin-521 may have the potential to promote lung injury in anti-GBM disease by increasing the total amount of IgG bound to the alveolar basement membranes.