Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice.

Meijing LiuGuohui ZhangChunge ZhengMeng SongFangle LiuXiaotao HuangShasha BaiXinan HuangChaozhan LinChenchen ZhuYingjie HuSuiqing MiChanghui Liu

Published in: British journal of pharmacology (2018)

IMP acts as a PXR agonist to attenuate DSS-induced colitis by suppression of the NF-κB-mediated pro-inflammatory response in a PXR/NF-κB-dependent manner.

Keyphrases

inflammatory response
lps induced
signaling pathway
pi k akt
nuclear factor
lipopolysaccharide induced
toll like receptor
oxidative stress
high fat diet induced
anti inflammatory
type diabetes
cell proliferation
adipose tissue
binding protein
immune response