Investigation of the Impact of Clonal Hematopoiesis on Severity and Pathophysiology of COVID-19 in Rhesus Macaques.
Tae-Hoon ShinYifan ZhouByung-Chul LeeSo Gun HongShayne F AndrewBarbara J FlynnMatthew GagneJohn-Paul M ToddIan N MooreAnthony CookMark G LewisKathryn E FouldsRobert A SederDaniel C DouekMario RoedererCynthia E DunbarPublished in: bioRxiv : the preprint server for biology (2023)
No evidence of association between CH and COVID-19 clinical severity in macaques.The presence of CH is associated with prolonged local inflammatory responses in COVID-19.SARS-CoV-2 persists longer in respiratory tracts of macaques with CH following infection.