Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis.

Haruka TsuchiyaMineto OtaHaruka TakahashiHiroaki HatanoMegumi OgawaSotaro NakajimaRisa YoshiharaTomohisa OkamuraShuji SumitomoKeishi Fujio

Published in: Inflammation and regeneration (2024)

JAKis and the TNFi had a direct impact on different RA risk enhancers, and we identified nucleotide-resolution targets for both drugs. Distinctive targets of clinically effective drugs could be useful for tailoring the application of these drugs and future design of more efficient treatment strategies.

Keyphrases

rheumatoid arthritis
disease activity
dna methylation
ankylosing spondylitis
systemic lupus erythematosus
copy number
risk assessment
climate change
single molecule