High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth.

Zhihua WangMiaomiao WangMengxin ZhangKaikun XuXinshuai ZhangYi XieYiming ZhangCheng ChangXiaolu LiAihua SunFuchu He

Published in: BMC medicine (2022)

Taken together, we reported several high-affinity SOAT1 ligands and demonstrated their clinical potential in the precision therapy of liver cancer, and also reveal the potential antitumor mechanism of SOAT1-targeting compounds.

Keyphrases

human health
quality improvement
genome wide
stem cells
single cell
risk assessment
gene expression
mesenchymal stem cells
low density lipoprotein
drug delivery
climate change